PAZAR - Links


Content

1. Useful Software
1.1 Introduction
1.2 Software Classes
1.3 Software List
2. Regulatory Datasets

For additional useful links see also http://bioinformatics.ubc.ca/resources/links_directory/?subcategory_id=104


1. Useful Software

1.1 Introduction

The data found within PAZAR can be used in association with a large array of online resources. We do not directly provide such tools within PAZAR. We believe the data should be accessed by sequence analysis tools through the PAZAR software interface. For now, one must still copy data from PAZAR and paste it into the web services you choose to use. The following list of resources is not comprehensive. If you have encountered a program that you think is noteworthy, please let us know.

1.2 Software Classes

Software Class Explanation
TFBS Discrimination Given a count matrix summarizing the binding sites for a TF, predict TFBS in a sequence of your choice.
Pattern Discovery Given a set of regulatory sequences, you wish to find new patterns that might be a novel type of TFBS.
TFBS Over-representation Given a set of genes and a count matrix, you wish to determine if the pattern defined by the count matrix is significantly enriched compared to background. Unfortunately there is no TFBS over-representation tool that allows for user-submitted binding profiles. Tools like oPOSSUM must analyze enormous numbers of genes to perform the analysis and therefore do not offer submission (yet).
TFBS Model Comparison You have recovered a new TFBS pattern (count matrix) and wish to see if the pattern resembles other known TFBS profiles. Once you find a pattern, it is natural to want to compare it against a database of patterns to see if it matches a characterized type of TFBS.
TFBS Combination Detection You have a set of TFBS count matrices (1 or more), and wish to find segments in a DNA sequence significantly enriched for combinations of matches to the pattern(s).
TF Information Sometimes you need to look up information about a gene or protein. Everyone knows about EnrezGene and UniProt. You might also try www.transcriptionfactors.org

1.3 Software List

Name Class(es) URL
AHAB TFBS Combination Detection http://gaspard.bio.nyu.edu/Ahab.html
Cluster Buster TFBS Combination Detection http://zlab.bu.edu/cluster-buster/cbust.html
ConSite TFBS Discrimination http://asp.ii.uib.no:8090/cgi-bin/CONSITE/consite/
CRE works TFBS Discrimination
TFBS Combination Detection
http://genereg.ornl.gov/scancre/
FOOTER TFBS Discrimination http://biodev.hgen.pitt.edu/footer_php/Footerv2_0.php
JASPAR TFBS Model Comparison http://jaspar.genereg.net/
MAST TFBS Discrimination
TFBS Combination Detection
http://meme.sdsc.edu/meme/mast.html
MSCAN TFBS Combination Detection
RSA TOOLS TFBS Discrimination
Pattern Discovery
http://rsat.ulb.ac.be/rsat/
STAMP TFBS Model Comparison http://www.benoslab.pitt.edu/stamp/
TOUCAN TFBS Discrimination
Pattern Discovery
TFBS Combination Detection
http://homes.esat.kuleuven.be/~saerts/software/toucan.php
WebMotifs Pattern Discovery http://fraenkel.mit.edu/webmotifs/


2. Regulatory Datasets

Name Description URL
ABS Database of Annotated regulatory Binding Sites from orthologous promoters http://genome.imim.es/datasets/abs2005/downloads.html
AGRIS AtcisDB and AtTFDB Arabidopsis thaliana cis-regulatory db and  transcription factor db http://arabidopsis.med.ohio-state.edu/
AtProbe Arabidopsis thaliana promoter binding element database http://rulai.cshl.edu/cgi-bin/atprobe/atprobe.pl
AthaMap Genome-wide map of potential transcription factor binding sites in Arabidopsis thaliana http://www.athamap.de/
BOND The Biomolecular Object Network Databank (BOND) is a resource to perform cross-database searches of available sequence, interaction, complex and pathway information. http://bond.unleashedinformatics.com/Action?
CEPDB C. elegans Promoter Db http://rulai.cshl.edu/cgi-bin/CEPDB/home.cgi
cisreg.ca Contains musle and liver data sets http://www.cisreg.ca/tjkwon/
Compel Composite regulatory elements: structure, function and classification http://compel.bionet.nsc.ru/new/compel/compel.html
DATF The Database of Arabidopsis Transcription Factors (DATF) http://datf.cbi.pku.edu.cn/
DBTSS Database of Transcriptional Start Sites http://dbtss.hgc.jp/
DoOP Orthologous clusters of promoters http://doop.abc.hu/
DBSD Drosophila Binding Site Database http://rulai.cshl.org/dbsd/index.html
*Note that this website is not yet functional but will be soon.
Drosophila DNase I Footprint Database Webpage providing access to results of the systematic curation and genome annotation of 1,365 DNase I footprints for the fruitfly D. melanogaster http://www.flyreg.org/
DRTF Database of Rice Transcription Factors http://drtf.cbi.pku.edu.cn/
ECRBase Database of Evolutionary Conserved Regions (ECRs), Promoters, and Transcription Factor Binding Sites in Vertebrate Genomes created using ECR Browser alignments http://ecrbase.dcode.org/
EDGEdb PDI, PPI and gene expression data generated by the Walhout laboratory and others are made available to the community through EDGEdb (elegans differential gene expression data) http://edgedb.umassmed.edu/IndexAction.do
EPD Eukaryotic Promoter Database http://www.epd.isb-sib.ch/
ERTargetDB  ERTargetDB integrates information from ongoing Chip-on-chip experiments and promoter sequence conservation from the OMGProm database. http://bioinformatics.med.ohio-state.edu/ERTargetDB/
Globin Gene Server Experimental data on the regulation of the globin gene cluster http://globin.cse.psu.edu/
Harbison Lab Datasets useful in comparative genomics and in erythroid gene regulation http://www.bx.psu.edu/~ross/dataset/DatasetHome.html
HemoPDB Hematopoiesis Promoter Db http://bioinformatics.med.ohio-state.edu/HemoPDB/
JASPAR high-quality transcription factor binding profile database. http://jaspar.cgb.ki.se/cgi-bin/jaspar_db.pl
LSPD The Liver Specific Gene Promoter Database http://rulai.cshl.edu/LSPD/
MPD Mammalian Promoter Db (human, mouse and rat) http://rulai.cshl.edu/CSHLmpd2
MPromDb Mammalian Promoter Db with experimentally supported annotations http://bioinformatics.med.ohio-state.edu/MPromDb/
MTIR Muscle-specific regulation of transcription http://www.cbil.upenn.edu/MTIR/HomePage.html
OMGProm Orthologous Mammalian Gene Promoters http://bioinformatics.med.ohio-state.edu/OMGProm/
ooTFD object-oriented Transcription Factors Db ttp://www.ifti.org/ootfd/
OPD Osteo-Promoter Db (promoters of genes in the osteogenic pathway) http://www.opd.tau.ac.il/
Oreganno Open regulatory annotation database http://oreganno.org
PLACE Plant Cis-acting Regulatory DNA Elements http://www.dna.affrc.go.jp/PLACE/
Plant CARE Cis-Acting regulatory element.database http://intra.psb.ugent.be:8080/PlantCARE/
*Note: This database does not appear to currently be online.
Plant Prom DB Plant Promoter Sequences http://mendel.cs.rhul.ac.uk/mendel.php?topic=plantprom
RARTF RIKEN Arabidopsis Transcription Factor db http://rarge.gsc.riken.jp/rartf/
REDfly Regulatory Element Database for Drosophila http://redfly.ccr.buffalo.edu/?content=/search.php
RiceTFDB Rice genes involved in transcriptional control http://ricetfdb.bio.uni-potsdam.de/v2.1/
RIKEN TFdb Mouse Transcription Factor Db http://genome.gsc.riken.jp/TFdb/
rSNP Influence of single nucleotide mutations in regulatory gene regions http://wwwmgs.bionet.nsc.ru/mgs/systems/rsnp/
SCPD S. cerevisiae Promoter Db http://rulai.cshl.edu/SCPD/
Stanford Encode Project ENCyclopedia Of DNA Elements http://www-shgc.stanford.edu/genetics/encode.html
transcription factors dd transcription factors of humans and other organisms http://www.proteinlounge.com/trans_home.asp
*Note: a subscription is required to view search results
TRANSFAC eukaryotic transcription factors and their binding profiles http://www.gene-regulation.de/
*Note: Downloads from the public version are not available
TRED Transcriptional Regulatory Element Database http://rulai.cshl.edu/cgi-bin/TRED/tred.cgi?process=home
TRRD Transcription Regulatory Regions Db http://wwwmgs.bionet.nsc.ru/mgs/gnw/trrd/
VISTA Enhancer Browser A database of tissue-specific human enhancers. http://enhancer.lbl.gov