The HIF1 TFBS project in PAZAR Help

Description

Compilation of binding sites for the HIF1 transcription factor complex composed of HIF1A and ARNT. The data was extracted from the following review:
[DOI: 10.1126/stke.3062005re12] Roland H. Wenger, Daniel P. Stiehl and Gieri Camenisch. Integration of oxygen signaling at the consensus HRE. (2005) Sci STKE. 306:re12.

Statistics

Regulated genes (or markers): 55
Regulatory sequences (genomic): 80
Regulatory sequences (artificial): 0
Transcription factors: 1
Transcription factor profiles: 0
Annotated publications: 61

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Homo sapiens
Mus musculus
Rattus norvegicus
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chromosome
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5'-nucleotidase, ecto ENSG00000135318
adrenomedullin ENSMUSG00000030790
aldolase A, fructose-bisphosphate ENSG00000149925
ATP-binding cassette, sub-family G , member 2 ENSG00000118777
Atrial natriuretic factorAuriculin-BAuriculin-AAtriopeptin-1Atriopeptin-2Atriopeptin-3 ENSRNOG00000008176
basic helix-loop-helix family, member e41 ENSG00000123095
BCL2/adenovirus E1B 19kDa interacting protein 3 ENSG00000176171
carbonic anhydrase IX ENSG00000107159
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ENSG00000164442
ceruloplasmin ENSG00000047457
chemokine ligand 12 ENSG00000107562
chemokine receptor 4 ENSG00000121966
DNA-damage-inducible transcript 4 ENSMUSG00000020108
egl nine homolog 1 ENSG00000135766
egl nine homolog 3 ENSG00000129521
endoglin ENSG00000106991
enolase 1, ENSG00000074800
erythropoietin ENSG00000130427
erythropoietin ENSMUSG00000029711
ferrochelatase ENSG00000066926
Glucokinase ENSRNOG00000014447
glutathione peroxidase 3 ENSG00000211445
glyceraldehyde-3-phosphate dehydrogenase ENSG00000111640
heat shock protein 90kDa beta , member 1 ENSG00000166598
heme oxygenase 1 ENSMUSG00000005413
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ENSG00000115738
insulin-like growth factor binding protein 1 ENSG00000146678
integrin, beta 2 ENSG00000160255
kinase insert domain protein receptor ENSMUSG00000062960
lactate dehydrogenase A ENSMUSG00000063229
matrix metallopeptidase 14 ENSG00000157227
met proto-oncogene ENSG00000105976
myeloid cell leukemia sequence 1 ENSG00000143384
nitric oxide synthase 2, inducible ENSMUSG00000020826
nitric oxide synthase 3 ENSG00000164867
nucleophosmin ENSG00000181163
Phosphoenolpyruvate carboxykinase, cytosolic ENSRNOG00000028616
phosphoglycerate kinase 1 ENSG00000102144
phosphoglycerate kinase 1 ENSMUSG00000062070
Plasminogen activator inhibitor 1 ENSRNOG00000001414
protein phosphatase 5, catalytic subunit ENSG00000011485
serpin peptidase inhibitor, clade E , member 1 ENSG00000106366
solute carrier family 2 , member 1 ENSMUSG00000028645
telomerase reverse transcriptase ENSG00000164362
transferrin ENSG00000091513
transferrin receptor ENSG00000072274
transforming growth factor, beta 3 ENSG00000119699
transforming growth factor, beta 3 ENSMUSG00000021253
trefoil factor 3 ENSG00000160180
v-ets erythroblastosis virus E26 oncogene homolog 1 ENSG00000134954
vascular endothelial growth factor A ENSG00000112715
Vascular endothelial growth factor A ENSRNOG00000019598
Wilms tumor 1 homolog ENSMUSG00000016458
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ADMC
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15688014
COMPILED
COMPUTATIONAL PREDICTION
DNASE I FOOTPRINTING
ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA)::DIRECT GEL SHIFT
ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA)::DIRECT GEL SHIFT WITH WESTERN BLOT DETECTION
ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA)::GEL SHIFT COMPETITION
ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA)::SUPERSHIFT
ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA)::UNKNOWN
EMSA
EXPERT CURATED::LITERATURE DERIVED
GENE CO-EXPRESSION::CO-EXPRESSED GENES DETERMINED THROUGH REPORTER GENE EXPERIMENTS
IN-VIVO HUMAN CD4 ASSAY
MUTAGENESIS::EXONUCLEASE DIGESTION
MUTAGENESIS::EXONUCLEASE III DIGESTION
MUTAGENESIS::OLIGONUCLEOTIDE SYNTHESIS
MUTAGENESIS::PCR
MUTAGENESIS::RESTRICTION ENDONUCLEASE DIGESTION
MUTAGENESIS::SITE-DIRECTED
MUTAGENESIS::UNKNOWN
N/A
NA
PROTEIN BINDING ASSAY :: CHROMATIN IMMUNOPRECIPITATION WITH TAG SEQUENCING (CHIP-TS)
PROTEIN BINDING ASSAY::CHROMATIN IMMUNOPRECIPITATION (CHIP)
PROTEIN BINDING ASSAY::CHROMATIN IMMUNOPRECIPITATION WITH TAG SEQUENCING (CHIP-TS)
PROTEIN BINDING ASSAY::DNA-PROTEIN PRECIPITATION ASSAY
PROTEIN BINDING ASSAY::DNA-PROTEIN PRECIPITATION ASSAY WITH ELISA DETECTION
PROTEIN BINDING ASSAY::DNASE FOOTPRINTING ASSAY
PROTEIN BINDING ASSAY::DNASE FOOTPRINTING COMPETITION ASSAY
PROTEIN BINDING ASSAY::IN-VIVO FOOTPRINTING ASSAY
PROTEIN BINDING ASSAY::METHYLATION INTERFERENCE
PROTEIN BINDING ASSAY::METHYLATION INTERFERENCE ASSAY
PROTEIN BINDING ASSAY::UNKNOWN
PROTEIN BINDING ASSAY::WESTERN BLOT ASSAY
PROTEIN BINDING ASSAY::YEAST 1-HYBRID ASSAY
PROTEIN EXPRESSION ASSAY::ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
PROTEIN EXPRESSION ASSAY::INDIRECT IMMUNOFLUORESCENCE
PROTEIN EXPRESSION ASSAY::LUCIFERASE EXPRESSION ASSAY
PROTEIN EXPRESSION ASSAY::WESTERN BLOT ASSAY
REPORTER GENE ASSAY
REPORTER GENE ASSAY:: TRANSIENT TRANSFECTION GENE EXPRESSION ASSAY
REPORTER GENE ASSAY:: TRANSIENT TRANSFECTION GENE EXPRESSION ASSAY WITH ELISA DETECTION
REPORTER GENE ASSAY::BETA-GLOBIN EXPRESSION ASSAY
REPORTER GENE ASSAY::CHLORAMPHENICOL ACETYLTRANSFERASE (CAT) ASSAY
REPORTER GENE ASSAY::DUAL LUCIFERASE REPORTER GENE ASSAY
REPORTER GENE ASSAY::IN-VITRO VIRUS REPLICATION ASSAY
REPORTER GENE ASSAY::IN-VIVO CHLORAMPHENICOL ACETYLTRANSFERASE (CAT) ASSAY
REPORTER GENE ASSAY::IN-VIVO GENE EXPRESSION ASSAY
REPORTER GENE ASSAY::IN-VIVO GFP EXPRESSION ASSAY
REPORTER GENE ASSAY::IN-VIVO LACZ EXPRESSION ASSAY
REPORTER GENE ASSAY::IN-VIVO LUCIFERASE EXPRESSION ASSAY
REPORTER GENE ASSAY::RABBIT BETA-GLOBIN EXPRESSION ASSAY
REPORTER GENE ASSAY::SECRETED ALKALINE PHOSPHATASE (SEAP) ASSAY
REPORTER GENE ASSAY::SITE-SPECIFIC STABLE TRANSFECTION GFP ASSAY BY CRE-LOX RECOMBINATION
REPORTER GENE ASSAY::STABLE TRANSFECTION CAT ASSAY
REPORTER GENE ASSAY::STABLE TRANSFECTION DSRED ASSAY
REPORTER GENE ASSAY::STABLE TRANSFECTION LACZ ASSAY
REPORTER GENE ASSAY::STABLE TRANSFECTION LUCIFERASE ASSAY
REPORTER GENE ASSAY::STABLY INCORPORATED GFP TRANSGENE ASSAY
REPORTER GENE ASSAY::TARGETED IN-VIVO EXPRESSION ASSAY BY IN UTERO ELECTROPORATION
REPORTER GENE ASSAY::TARGETED IN-VIVO GENE EXPRESSION ASSAY BY NON-VIRAL INJECTION
REPORTER GENE ASSAY::TARGETED IN-VIVO GFP EXPRESSION ASSAY BY VIRAL INJECTION
REPORTER GENE ASSAY::TARGETED IN-VIVO LACZ EXPRESSION ASSAY BY VIRAL INJECTION
REPORTER GENE ASSAY::TRANSIENT TRANSFECTION GENE EXPRESSION ASSAY
REPORTER GENE ASSAY::TRANSIENT TRANSFECTION GFP ASSAY
REPORTER GENE ASSAY::TRANSIENT TRANSFECTION HUMAN GROWTH HORMONE ASSAY
REPORTER GENE ASSAY::TRANSIENT TRANSFECTION LACZ ASSAY
REPORTER GENE ASSAY::TRANSIENT TRANSFECTION LUCIFERASE ASSAY
REPORTER GENE ASSAY::UNKNOWN
REPORTER GENE ASSAY::VIRAL INFECTION LUCIFERASE ASSAY
RNA EXPRESSION ASSAY::IN-VITRO TRANSCRIPTION ASSAY WITH DETECTION BY PRIMER EXTENSION
RNA EXPRESSION ASSAY::NORTHERN BLOT
RNA EXPRESSION ASSAY::PRIMER EXTENSION ANALYSIS WITH POLY(A)+ RNA
RNA EXPRESSION ASSAY::REAL TIME PCR
RNA EXPRESSION ASSAY::REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION (RT-PCR)
RNA EXPRESSION ASSAY::RNASE PROTECTION ASSAY (RPA)
RNA EXPRESSION ASSAY::WHOLE-MOUNT IN SITU HYBRIDIZATION
RNA STABILITY ASSAY::RNA SYNTHESIS BLOCKING
SELEX
SEQUENCE CONSERVATION::CO-EXPRESSED GENE CONSERVATION
SEQUENCE CONSERVATION::CONSERVATION FOUND BY ALIGNMENT
SEQUENCE CONSERVATION::ORTHOLOGOUS GENE CONSERVATION
SITE-DIRECTED MUTAGENESIS
UNKNOWN::CHROMATIN IMMUNOPRECIPITATION (CHIP)
UNKNOWN::UNKNOWN
YEAST ONE-HYBRID
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