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The P130_Chicas_quiescent_shRb project in PAZAR
Description The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a nonredundant role in tumor suppression. We demonstrate that RB preferentially associates with E2F target genes involved in DNA replication and is uniquely required to repress these genes during senescence but not other growth states. Consequently, RB loss leads to inappropriate DNA synthesis following a senescence trigger and, together with disruption of a p21-mediated cell-cycle checkpoint, enables extensive proliferation and rampant genomic instability. Our results identify a nonredundant RB effector function that may contribute to tumor suppression and reveal how loss of RB and p53 cooperate to bypass senescence.
Statistics
Regulated genes (or markers): 4824
Regulatory sequences (genomic): 4640 Regulatory sequences (artificial): 0 Transcription factors: 1 Transcription factor profiles: 0 Annotated publications: 1 Generate GFFIf you would like to generate a current GFF file for this project immediately, click the button below to do so. The file will be made available for download in a new window. The new window may be safely closed once you have downloaded the file. Note that GFF file generation may take a significant amount of time for larger projects.Pre-generated GFF files are available in the downloads section. Public projects are checked weekly and updated files are generated if there are changes. Access project data |